Lab Publications

Jiang, A., Zhao, C., Sheffield. M.E. A preprocessing toolbox for 2-photon subcellular calcium imaging. bioRxiv, (2024).

Heer, C.M., Sheffield, M.E. Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments. eLife 13 (2024).

Madar, A.D., Dong, C., Sheffield, M.E. The Rules of Synaptic Plasticity Driving Representational Shifting in the Hippocampus. Accepted at Nature Neuro bioRxiv, (2024).

Chiu, Y., Dong, C., Krishnan, S. & Sheffield, M.E. The Precision of Place Fields Governs Their Fate Across Epochs of Experience. eNeuro, 0261-23 (2023).

Ratigan, H.C., Krishnan, S., Smith, S., Sheffield, M.E. A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination. Nat Commun, 14, 6758 (2023). See this link for press release on this work.

Krishnan, L.S., Heer, C., Cherian, C., Sheffield, M.E. Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal. Nat Commun 13, 6662 (2022).

Dong, C., Madar, D.A., Sheffield, M.E. Distinct place cell dynamics in CA1 and CA3 encode experience in new environments. Nat Commun 12, 2977 (2021).

Wildenberg, G., Sorokina, A., Koranda, J., Monical, A., Heer, C., Sheffield, M.E., Zhuang, X., McGehee, D., and Kasthuri, B. Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine. eLife 10 (2021).

Sheffield, M.E. & Dombeck, D.A. Dendritic mechanisms of hippocampal place field formation. Curr Opin Neurobiol. 20;54:1-11 (2018). 

Spotlight review of the Neuron paper below: Schiller, J., Berlin S., Derdikman, D. The Many Worlds of Plasticity Rules. TINS 41, 124-127 (2018).

Sheffield, M.E., Adoff M. D., Dombeck D. A. Increased prevalence of calcium transients across the dendritic arbor during place field formation. Neuron 96, 490-504 (2017).

Sheffield, M.E. & Dombeck, D.A. The binding solution? Nat Neurosci 18, 1060-1062 (2015). News and Views.

Sheffield, M.E. & Dombeck, D.A. Calcium transient prevalence across the dendritic arbour predicts place field properties. Nature 517, 200-204 (2015). (recommended by Faculty of 1000).

Research Highlight on: Calcium transient prevalence across the dendritic arbour predicts place field properties: Yates, D. Dendrites: regenerating space. Nat Rev Neurosci 15, 766 (2014).

Sheffield, M.E., Edgerton, G.B., Heuermann, R.J., Deemyad, T., Mensh, B.D., Spruston, N. Mechanisms of retroaxonal barrage firing in hippocampal interneurons. J Physiol 591, 4793-4805 (2013).

Sheffield, M.E., Best, T.K., Mensh, B.D., Kath, W.L. & Spruston, N. Slow integration leads to persistent action potential firing in distal axons of coupled interneurons. Nat Neurosci 14, 200-207 (2011). (recommended by Faculty of 1000).

News and Views on: Slow integration leads to persistent action potential firing in distal axons of coupled interneurons Connors, B.W. & Ahmed, O.J. Integration and autonomy in axons. Nat Neurosci 14, 128-130 (2011).